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Pre-clinical heart transplantation studies have shown that ex vivo non-ischemic heart preservation (NIHP) can be safely used for 24 h. Here we perform a prospective, open-label, non-randomized phase II study comparing NIHP to static cold preservation (SCS), the current standard for adult heart transplantation. All adult recipients on waiting lists for heart transplantation were included in the stu

https://www.lupop.lu.se/article/nonrandomized-open-label-phase-2-trial-nonischemic-heart-preservation-human-heart-transplantation - 2025-10-25

The rapid development of new therapies in metastatic breast cancer (MBC), entails a need for improved prognostic and monitoring tools. Thymidine kinase 1 (TK1) is involved in DNA synthesis and its activity correlates to outcome in cancer patients. The aim of this study was to evaluate serum TK1 activity (sTK1) levels in MBC patients as a tool for prognostication and treatment monitoring. Read more

https://www.lupop.lu.se/article/serial-evaluation-serum-thymidine-kinase-activity-prognostic-women-newly-diagnosed-metastatic-breast - 2025-10-25

Much neighborhood research has focused on contemporary and segregated cities in the United States, but less on small and more homogenous cities. Additionally, neighborhood conditions are often estimated using administrative borders, which bias results. We adopt a long-term perspective on the importance of childhood neighbors, using more realistic methods of neighborhood conditions. We estimate ind

https://www.lupop.lu.se/article/social-context-nearest-neighbors-shapes-educational-attainment-regardless-class-origin - 2025-10-25

The prevalence of low LTPA among men and women were as follows: 13.9% and 12.3% among heterosexuals, 26.1% and 18.5% among bisexuals, 19.5% and 15.6% among homosexuals, 26.6% and 18.5% among others. Bisexual men and women and other men had higher odds ratio of low LTPA than heterosexuals in the final models, whereas gay and lesbian participants did not differ. Read more at Sexual identity and low

https://www.lupop.lu.se/article/sexual-identity-and-low-leisure-time-physical-activity-population-based-study - 2025-10-25

Poor health and unmet healthcare needs is common among people with substance use disorder (SUD) including patients in opioid substitution treatment (OST). Low health literacy (HL) is associated with poverty, low education and physical limitations, but is unexplored in an OST context. Read more at Health Literacy among Swedish Patients in Opioid Substitution Treatment: A Mixed-Methods Study - Scien

https://www.lupop.lu.se/article/health-literacy-among-swedish-patients-opioid-substitution-treatment-mixed-methods-study - 2025-10-25

A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 1998 and December 31, 2012. Cox regression analysis was used to estimate the relative risk (hazard ratios (HR) with 95% confidence intervals (CI)) of incident forearm fractures compared to Swedish-born ind

https://www.lupop.lu.se/article/distal-forearm-fractures-immigrant-groups-national-swedish-study - 2025-10-25

Parents and teachers play an important role in stimulating student motivation. The aim of this study was to examine if both parent and teacher enthusiasm could predict intrinsic motivation toward STEM activities, and if motivation would be associated with improved STEM achievement over one year in a one-year prospective examination of 288 Swedish students in their final year of a Science High Scho

https://www.lupop.lu.se/article/examining-how-parent-and-teacher-enthusiasm-influences-motivation-and-achievement-stem - 2025-10-25

The aim of this study was to establish creatinine growth curves separately for males and females that can be used to adjust childhood levels of serum creatinine to corresponding adult levels. Linear regression with fractional polynomials of age as independent variable was used to construct creatinine growth curves for a reference cohort (n = 83,157 samples from Belgium and Sweden, age 2–40 years).

https://www.lupop.lu.se/article/novel-method-creatinine-adjustment-makes-revised-lund-malmo-gfr-estimating-equation-applicable - 2025-10-25

Thirty participants were randomized to the intervention group with four lifestyle-promoting text messages sent every week for six months. The control group received usual care. The baseline and follow-up visits for all 60 patients included measurements of blood pressure, anthropometrics, blood tests and a self-reported questionnaire. Read more at Full article: Text message-based lifestyle interven

https://www.lupop.lu.se/article/text-message-based-lifestyle-intervention-primary-care-patients-hypertension-randomized-controlled - 2025-10-25

We investigated use of the six major H1-antihistamines (cetirizine, clemastine, desloratadine, ebastine, fexofenadine and loratadine) and breast cancer-specific and overall mortality in a nation-wide register-based study of all 61,627 Swedish women diagnosed with breast cancer 2006–2013. Both peri- and post-diagnostic antihistamine use was analyzed using Cox regression models. Analyses were strati

https://www.lupop.lu.se/article/desloratadine-and-loratadine-stand-out-among-common-h1-antihistamines-association-improved-breast - 2025-10-25

Cognitive function is an important outcome measure in patients with brain tumor, providing information about the patient’s clinical situation, treatment effects and possible progressive disease. The aim of this longitudinal study was to evaluate effects of the currently used radiation and chemotherapy treatment on cognitive function and to investigate associations between cognitive function at bas

https://www.lupop.lu.se/article/longitudinal-study-cognitive-function-glioma-patients-treated-modern-radiotherapy-techniques-and - 2025-10-25

Unacceptable pain was frequent. At the 15 year follow-up visit, 34% had unacceptable pain. Patients with unacceptable pain had, compared with patients with tolerable pain, significantly more disease activity, worse patient global assessment, and worse function on the Health Assessment Questionnaire and Signals of Functional Impairment, but the degree of joint destruction was similar. Disease-modif

https://www.lupop.lu.se/article/unacceptable-pain-barfot-inception-cohort-patients-rheumatoid-arthritis-long-term-study - 2025-10-25

An increasing number of people will live with disabilities in their homes and consequently, the need for home-based interventions will increase. Housing adaptations (HAs) are modifications to the physical home environment with the purpose to enhance independence for a heterogeneous group of people. Increasing the knowledge of the characteristics of HA clients by exploring their heterogeneity, coul

https://www.lupop.lu.se/article/identifying-and-validating-housing-adaptation-client-profiles-mixed-methods-study - 2025-10-25

As institutional forms of political engagement continue to decline, participation in protests steadily become more common. These trends are particularly strong among younger citizens. Previous research indicates that social factors can explain participation in political protests, and that younger citizens’ participation in protests is more affected by social ties than older people’s participation.

https://www.lupop.lu.se/article/young-protester-impact-belongingness-needs-political-engagement - 2025-10-25

Malmö city, Sweden had 322,574 inhabitants in 2015. We used diagnosis registry, charts, and radiographs of the only city hospital to classify fractures in individuals < 16 years in 2014–2016, and compared these with data from 1950–2006. We used joinpoint regression to analyze time trends and present results as mean annual percentage changes (APC). Differences between periods are described as incid

https://www.lupop.lu.se/article/time-trends-pediatric-fractures-swedish-city-1950-2016 - 2025-10-25

Two academic centers in Lithuania and Turkey participated in this retrospective study conducted between November 2018 and July 2019. A total of 100 consecutive patients (22 males, 78 females; mean age 78.9 years; range, 45 to 100 years) with low energy proximal femur fractures admitted for surgery were included in the study. Fracture Risk Assessment tool (FRAX) and the Sernbo scores were calculate

https://www.lupop.lu.se/article/combined-fracture-and-mortality-risk-evaluation-stratifying-treatment-hip-fracture-patients - 2025-10-25

Recent improvements in life expectancy in many countries stem from reduced mortality from cardiovascular disease and cancer above the age of 60. This is the combined result of decreased incidence and improved survival among those with disease. The latter has led to a higher proportion in the population of people with a past history of disease. This is a group with higher mortality than the general

https://www.lupop.lu.se/article/rise-number-long-term-survivors-different-diseases-can-slow-increase-life-expectancy-total - 2025-10-25

Global environmental change has degraded ecosystems. Challenges such as climate change, resource depletion (with its huge implications for human health and wellbeing), and persistent social inequalities in health have been identified as global public health issues with implications for both communicable and noncommunicable diseases. This contributes to pressure on healthcare systems, as well as so

https://www.lupop.lu.se/article/advancing-global-health-through-environmental-and-public-health-tracking-0 - 2025-10-25

International patient registries are of particular importance for rare disorders, as they may contribute to overcome the lack of knowledge derived from low number of patients and limited awareness of these diseases, and help to learn more about their geographical or population-based specificities, which is relevant for research purposes and for promoting better standards of care and diagnosis. Our

https://www.lupop.lu.se/article/creation-and-implementation-european-registry-patients-mcardle-disease-and-other-muscle-glycogenoses - 2025-10-25

Dominant mutations in valosin-containing protein (VCP) gene cause an adult onset inclusion body myopathy, Paget’s disease of bone, and frontotemporal dementia also termed multisystem proteinopathy (MSP). The genotype-phenotype relationships in VCP-related MSP are still being defined; in order to understand this better, we investigated the phenotypic diversity and patterns of weakness in the Cure V

https://www.lupop.lu.se/article/phenotypic-diversity-international-cure-vcp-disease-registry - 2025-10-25